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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lessen panobinostat concentrations by ~70% and produce cure failure.pentobarbital improves effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Watch. Coadministration of